A quantitative structure–activity relationship (QSAR) study was conducted to address an important problem encountered in the prediction of the Bioconcentration Factors (BCF) of highly hydrophobic chemicals. The results suggested that a non-linear relationship between BCF and the hydrophobic parameter, along with inclusion of additional molecular size, weight and/or volume parameters, should be considered while developing a QSAR model for more reliable prediction of the BCF of highly hydrophobic chemicals.1Source: Garg, Rajni, and Carr J. Smith. “Predicting the bioconcentration factor of highly hydrophobic organic chemicals.” Food and Chemical Toxicology 69 (2014): 252-259.