The findings from this rat 90-day oral toxicity study concluded that TBBPA had no effect on mortality, clinical signs, body or organ weights, histopathology, urinalysis, ophthalmology, and several blood serum chemistries.
Key Takeaways:
- The study found that TBBPA exerted no marked effect on the rate of mortality, clinical signs, body or organ weights, feed consumption, histopathology, urinalysis, ophthalmology, and neurological outcomes in a functional observation battery, motor activity, serum thyroid stimulating hormone, serum triiodothyronine, or other serum chemistries.
- Derived a No Observed Adverse Effect Level (NOAEL) that was at least 1,000 mg/kg/day, the highest dose tested.
- Based on an upper bound aggregate exposure for adults estimated by the European Union, the margin of exposure is approximately 5,000, suggesting that, for the endpoints examined in this study, exposure to TBBPA presents a reasonable certainty of no harm.