This review analyzed several modes of action (MoA) that may account for the observed effects from TBBPA exposure seen in animal studies. The study concluded that the potential MoA for thyroid changes induced by TBBPA are expected to exhibit a threshold for adverse effects.1 Source: Lai, David Y., Sam Kacew, and Wolfgang Dekant. “Tetrabromobisphenol A (TBBPA): Possible modes of action of toxicity and carcinogenicity in rodents.” Food and Chemical Toxicology 80 (2015): 206-214.