Absence of Neurotoxicity and Lack of Neurobehavioral Consequences Due to Exposure to Tetrabromobisphenol A (TBBPA) Exposure in Humans, Animals and Zebrafish

This review assesses toxicokentic studies evaluating TBBPA and its effects on metabolic processes and health. The findings show that TBBPA does not accumulate in the body and there is no evidence that the parent compound is present in the brain. Although this brominated flame retardant was detected in human breast milk and serum, there was no evidence that TBBPA reached the brain in in vivo animal studies as reflected by the absence of neuropathological, neurotoxic, or behavioral alterations indicating that the central nervous system is not a target tissue.1Source: Absence of neurotoxicity and lack of neurobehavioral consequences due to exposure to tetrabromobisphenol A (TBBPA) exposure in humans, animals and zebrafish

Key Takeaways:

  • TBBPA is not a neurotoxin
  • Brain tissue is not a target of TBBPA
  • Physicochemical properties of TBBPA make it unlikely to dissolve in media to enter humans/animals
  • There is a high conversion/metabolic rate of TBBPA to its conjugate, indicating low bioavailability with limited to no retention
  • TBBPA does not accumulate in fat tissue